ISCOMATRIX: a novel adjuvant for use in prophylactic and therapeutic vaccines against infectious diseases

Use of Sodium Alginate Adjuvant in Preparation of a Formalin Killed Vaccine Against Infectious Bovine Rhinotracheitis

Prospects for prophylactic and therapeutic vaccines against hepatitis C virus.

Natural cross-protective immunity is induced after spontaneous clearance of primary hepatitis C virus (HCV) infection. Although this suggests that effective prophylactic vaccines against HCV are possible, there are still several areas that require further study. Current data indicate that, at best, vaccine-induced immunity may not completely prevent HCV infection but rather prevent persistence ...

New Vaccines against Epidemic Infectious Diseases.

conditions.1-3 Governments and foundations mobilized funds quickly. Companies and research-anddevelopment institutions brought vaccine candidates into the field. Collaborations among the World Health Organization (WHO), funders, academia, civil society, and industry saw vaccines advancing through more than 15 accelerated clinical trials in a year. But the testing of Ebola vaccine candidates had...

Therapeutic Vaccines Against Cancer and Autoimmune Diseases

Elucidation of antigenicity and immunogenicity My laboratory pioneered the design of amino acid oligomers to define the minimal and precise chemical characteristics of antigens – molecules that could be bound by antibodies (1). Using these tools, we determined the functional size of the antibody binding pocket, and characterized the effects of charge, hydrophobicity, and side chain interactions...

AAV Vectors Vaccines Against Infectious Diseases

Since their discovery as a tool for gene transfer, vectors derived from the adeno-associated virus (AAV) have been used for gene therapy applications and attracted scientist to this field for their exceptional properties of efficiency of in vivo gene transfer and the level and duration of transgene expression. For many years, AAVs have been considered as low immunogenic vectors due to their abi...